Resistance To Skincare Products : What To Do When Your Fav Creams Stop Working !!!
Today, after a long break I’m going to discuss about a much
interesting topic, although ignored by most & atleast till date, I had to
run google search atleast 300 times to get an insight of skincare
product/ointment resistance. I don’t know why but no one seems to address this
while this is a debilitating problem for most skincare-savvy people in the
world.
Let me describe the problem in detail first.
We’ve always (atleast once in our lifetime) faced this
problem. Like if you’re using a specific product for about 3 months in a row
& suddenly discover that it is not working anymore. Now this problem is
much pronounced with those if you’re using the product to achieve a certain
result, like removing a scar, fading hyperpigmentation like treating melasma or
post inflammatory hyperpigmentation or acne scars.
Only that if you’re using a product to do a specific job,
you’d notice that after using it for a while, it’ll eventually stop improving.
You’d hit a plateau. Now mostly if you’re using a random skincare product just
for maintenance & not expecting certain changes (like brightening, fading
scars etc.), this resistance that’s developed after using it for a while would
certainly go unnoticed.
Here the word ‘resistance’ shall only be used in a case
where a certain product is used in order to target a specific concern (like
scars/inflammation/erythema or redness/acne etc.) & it is used for atleast
3 months in a row & in the beginning it was working (meaning, it cured or
atleast helped the specific concern) but after a while (like after a month or
more it suddenly doesn’t seem to work or it simply becomes ineffective on the
same concern it used to treat successfully previously).
It is then assumed that your skin has developed resistance
towards the product. It is the time we should usually discontinue the same
& revamp the targeted skincare routine.
Here I’ll discuss a few pronounced cases of resistance &
ways out. Most of them are from personal experience. Those who read my blog,
knows what a skincare geek I am & before achieving a spotless skin, I’ve
gone through all the popular concerns you can possibly imagine: acne, acne
scars, chemical peel gone wrong (post inflammatory hyperpigmentation), uneven
skintone, horribly oily skin & the list goes on. So, I’ve frequently
experienced product resistance.
Well I believe everyone has experienced some form of product
resistance but it has gone unnoticed because it was no targeted therapy. Like
those developing resistance towards cosmetic products like creams,
moisturizers, serums & all.
There is no remedy that fits all but most commonly when you
notice your old beloved cream doesn’t work anymore (maybe your skin isn’t
improving & those problems although seems a bit better but suddenly does
not improve anymore), its better to switch product & choose one with a
different composition this time & I’m talking about the principle
ingredient here & not the additives like preservatives & all.
Now let’s talk about common incidents where we develop
resistance to popular ointments based on the following;
·
Hydroquinone
Resistance : Hydroquinone is a
heavily disputed ingredient in popular scar lightening ointments. This is a ‘tyrosinase
inhibitor’, meaning an agent that stops tyrosinase (an enzyme that facilitates
melanin synthesis from tyrosine) from acting & thus stops melanin
synthesis. Melanin is the reason for hyperpigmentation or scars or darkening of
skintone.
Hydroquinone is very effective as a scar lightening
treatment option, although it has many side effects upon long term exposure
& is also banned in some countries because of the potential hazards
associated with it. However still some individuals prefer using it (ofcourse
under strict medical supervision) & eventually may develop resistance
towards it.
Initially it’d work like magic & depigment the scars
fast but if continued for long (which is also dangerous), you may start notice
that your scars aren’t improving anymore. It means you’ve developed resistance
to it (and unfortunately resistance develops as rapidly as it depigments those
scars).
In such a case, immediately stop applying the ointment &
substitute it with any of its derivatives. There are many newly introduced
derivatives of hydroquinone which are not only as effective as HQ but would
still work in case you develop resistance to HQ.
Such popular yet effective derivatives/alternatives you may
use are Arbutin & Kojic Acid.
Now, you’d find them mostly together as a combination in an
ointment & it is perfectly good to use. Kojic acid is a highly unstable
agent & thus you’d mostly find its stable cousin ‘Kojic Acid Dipalmitate’
in an ointment.
When you develop resistance to hydroquinone & stop using
the ointment; I generally suggest you to give a window period of a week atleast
before resuming treatment with another ointment based on its derivatives like
suggested above.
You’d soon observe the improvement on resuming treatment
with these alternatives & after a few months, you may begin treatment with
hydroquinone again & see if it starts working again. It usually will only
that you need a gap period between the two phases, no matter if you use
something alternative in between or not.
·
Arbutin +
Kojic Acid Resistance: I generally do not suggest using hydroquinone to
depigment scars but in a case of resistance to the mentioned combination; it
can be used if you may deem it safe for use or your physician suggests.
Also there are safer alternatives who do the same job have
been introduced recently such as Azelaic acid. It is perceived that 20% azelaic
acid is equivalent to 4% hydroquinone & 10% azelaic acid is equivalent to 2%
hydroquinone. So Azelaic acid ointment can be used safely in case of both
Arbutin + Kojic Acid Dipalmitate combination resistance or Hydroquinone
resistance.
There’s a fun fact worth mentioning.
Azelaic acid is not only used to depigment scars or post
inflammatory hyperpigmentation but also to heal stubborn acne. In fact it is
primarily used as a safe & potent treatment option for acne. So it can also
be used as an alternative if you develop resistance to a topical ointment for
acne like tretinoin etc.
·
Acne
Specific Ointment Resistance: Popularly for acne, most physicians suggest
retinoid based ointments for acne & the family includes everything from
traditional accutane or isotretinoin to tretinoin to the newest member of this
family : adapalene & tazarotene.
Upon developing resistance to any one of them, any other
agent from the same retinoid family can be used to continue treatment. Adapalene
0.1% is very potent in doing the same in case tretinoin stops working.
Tazarotene is more of a depigmenting agent for melasma but
it is also used off-label to treat comedones (acne bumps). As I said before,
azelaic acid can also be used as an alternative.
The thing is, these agents work as chemical exfoliants that
shed the outer layer of skin (outermost layer of epidermis) & in the
process, gets the skin rid of acne causing bacteria & damaged dead skin
cells.
·
AHA or
BHA resistance: AHA refers to the family of alpha hydroxy acids which
includes glycolic acid as the most popular member & BHA is Beta Hydroxy
Acid which includes salicylic acid.
AHA or BHA both work the same way just like topical
retinoids by shedding the outer damaged layer & they conquer both:
hyperpigmentation & acne & in both cases, they can be used
alternatively. In case you develop resistance to AHA, you can begin treatment
with salicylic acid.
The fun fact is salicylic acid as a BHA (as with any BHA in
that case) penetrates deeper than any AHA (like glycolic acid).
Also AHA or BHA, both can be used in case you develop
resistance to retinoids or vice versa.
So this is what all I knew from experience. Glycolic acid
worked wonderfully when I developed resistance towards retinoids or
hydroquinone (depigmentation purpose). Azelaic acid, strangely never worked for
me.
This is a generalized idea from my experience.
Also, above are only recommendations of products that is
known to combat skincare product resistance & this is for educational purpose only; thus it
cannot be treated as an alternative to a medical professional’s advice. Please
refer to the disclaimer for further information: https://thebeautyblogoflove.blogspot.com/p/disclaimer.html
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Love,
Koyel M.
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